Bidirectional Regulation of NAD(P)H Quinone Dehydrogenase 1 Expression in Mouse Hepatic Stellate Cells- Acute versus Long-Term Ethanol Exposure
نویسندگان
چکیده
Conclusions: Our findings suggest that ethanol upregulates NQO1 expression by activating the AhR-Nrf2 pathway. Long-term exposure sustains low level of AhR protein and diminishes inducibility its target genes Nrf2 BaP. These will contribute to understanding synergistic toxicity polycyclic aromatic hydrocarbon compounds, such as
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ژورنال
عنوان ژورنال: Medical research archives
سال: 2023
ISSN: ['2375-1916', '2375-1924']
DOI: https://doi.org/10.18103/mra.v11i2.3586